Detalhe da pesquisa
1.
Inducing and exploiting vulnerabilities for the treatment of liver cancer.
Nature
; 574(7777): 268-272, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31578521
2.
Double-strand break toxicity is chromatin context independent.
Nucleic Acids Res
; 50(17): 9930-9947, 2022 09 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36107780
3.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 508(7495): 215-21, 2014 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24695224
4.
Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer.
J Hepatol
; 69(5): 1057-1065, 2018 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-30030148
5.
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 544(7651): 508, 2017 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28447629
6.
Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.
Proc Natl Acad Sci U S A
; 110(13): 5139-44, 2013 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-23483055
7.
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.
Cancer Cell
; 10(5): 437-49, 2006 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-17097565
8.
DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II.
Nat Commun
; 13(1): 3624, 2022 06 24.
Artigo
Inglês
| MEDLINE | ID: mdl-35750669
9.
Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium.
Curr Biol
; 18(14): 1094-9, 2008 Jul 22.
Artigo
Inglês
| MEDLINE | ID: mdl-18635350
10.
A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis.
J Pathol
; 220(1): 34-44, 2010 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19927317
11.
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.
Nat Cell Biol
; 23(6): 608-619, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34108662
12.
The Good, the Bad, and the Ugly: in search of gold standards for assessing functional genetic screen quality.
Mol Syst Biol
; 10: 738, 2014 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24987117
13.
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.
Breast Cancer Res
; 11(4): R63, 2009.
Artigo
Inglês
| MEDLINE | ID: mdl-19709408
14.
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.
Clin Cancer Res
; 14(12): 3916-25, 2008 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18559613
15.
ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors.
Oncogene
; 37(33): 4611-4625, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29760405
16.
The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.
Cell Rep
; 23(7): 2107-2118, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29768208
17.
High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer.
Cell Rep
; 21(3): 773-783, 2017 Oct 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29045843
18.
Pooled shRNA Screening in Mammalian Cells as a Functional Genomic Discovery Platform.
Methods Mol Biol
; 1470: 49-73, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27581284
19.
CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.
Nat Biotechnol
; 34(6): 631-3, 2016 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-27111720
20.
The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.
Cancer Res
; 76(20): 6084-6094, 2016 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27550455